Colin Smith, Assistant Professor
Biology Department, American University of Beirut
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Graduate and medical school advice

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Patents
  • Schroff M., Smith C. Circular Expression Construct for Gene Therapeutic Applications (EP 1 631 672) European Patent Office (2006).

  • Smith C., Huppertz A., Wittig B. DNA Expression Construct for Multiple Gene Expression (EP 1 530 641) European Patent Office (2005).
Publications
  • Haykal J., Geara F., Haddadin M.J., Smith C.A. & Gali-Muhtasib H. The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells. Radiation Oncology 4, 25 (2009). pdf(776 KB)

  • Sayar N.P., Smith C.A., White I.M. & Knio K.M. Terellia fuscicornis (Diptera: Tephritidae): biological and morphological adaptation on artichoke and milk thistle. Journal of Natural History, 43, 1159-1181 (2009).

  • Smith C.A., Al-Zein M.S., Sayar N.P., & Knio K.M. Host races in Chaetostomella cylindrica (Diptera: Tephritidae): genetic and behavioural evidence. Bulletin of Entymological Research, 99, 425-32 (2009). pdf(125KB)

  • Cocozaki A.I., Ghattas I.R. & Smith C.A. The RNA-Binding Domain of P22 N Protein Is Highly Mutable and a Single Mutation Relaxes Specificity Toward Lambda. Journal of Bacteriology 190, 7699-7708 (2008). pdf(502KB)

  • Asraoui J., Sayar N.P., Khouzama K.M. & Smith C.A.* Fly diversity revealed by PCR-RFLP of mitochondrial DNA. Biochemistry and Molecular Biology Education 36, No.5, 354-362 (2008). pdf(218KB)

  • Cocozaki A.I., Ghattas I.R. & Smith C.A.* Bacteriophage P22 antitermination boxB sequence requirements are complex and overlap with those of Lambda. Journal of Bacteriology 190, 4263–4271 (2008). pdf(366KB)

  • Haykal J., Fernainya P., Itania W., Haddadin M., Geara F., Smith C.* & Gali-Muhtasib H.* Radiosensitization of EMT6 mammary carcinoma cells by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide. Radiotherapy and Oncology 86, 412–418 (2008). pdf(549KB)

  • Moreno S., Lopez-Fuertes L., Vila-Coro A.J., Sack F., Smith C.A., Konig S.A., Wittig B., Schroff M., Juhls C., Junghans C., Timon M. (2004). DNA Immunisation with Minimalistic Expression Constructs. Vaccine 22, 1709-1716.

  • Smith, C.A., Calabro, V., and Frankel, A.D. (2000). An RNA binding chameleon.
    Molecular Cell 6: 1067-1076. pdf (448KB)

  • Smith, C.A., Chen, L. & Frankel, A.D. (2000). Using Peptides as Models of RNA-Protein Interactions. Methods Enzymol. 318, 423-438.

  • Peled-Zehavi, H., Smith, C.A., Harada, K. & Frankel, A.D. Screening RNA-Binding Libaries by Transcriptional Antitermination in Bacteria. Methods Enzymol. 318, 297-308 (2000).

  • Smith, C.A., Crotty, S., Harada, Y. & Frankel, A.D. Altering the Context of an RNA Bulge Switches the Binding Specificities of Two Viral Tat Proteins. Biochemistry 37, 10808-10814 (1998). pdf file (168 KB)

  • Frankel, A.D. & Smith, C.A. Induced Folding in RNA-Protein Recognition: More than a Simple Molecular Handshake. Cell 92, 149-151 (1998).

  • Smith, C.A., Jared, B., and Taylor, J.-S. (1998).
    The ability of a variety of polymerases to synthesize past site specific cis-syn, trans-syn-II, (6-4), and Dewar photoproducts of thymidylyl-(3'-5')-thymidine.
    J.Biol.Chem. 273 (34): 21933-21940. pdf file (389 KB)

  • Jen, J., Mitchell, D.L., Cunningham, R.P., Smith, C.A., Taylor, J.-S. & Cleaver, J.E. Ultraviolet Irradiation Produces Novel Endonuclease III-Sensitive Cytosine Photoproducts at Dipyrimidine sites. Photochem. Photobiol. 65, 323-329 (1997)

  • Smith, C.A., Wang, M., Jiang, N., Che, L., Zhao, X., and Taylor, J.-S. (1996). Mutation spectra of M13 vectors containing site-specific cis-syn, trans-syn-I, (6-4), and dewar pyrimidone photoproducts of thymidylyl-(3'-5')-thymidine in Escherichia coli under SOS conditions. Biochem. 35: 4146-4154. pdf file (462 KB)

  • Bowman, K.K., Sidik, K., Smith, C.A., Taylor, J.-S., Doetsch, P.W. & Freyer, G.A.(1994). A New ATP-Independent DNA Endonuclease from Schizosaccharomyces pombe that Recognizes Cyclobutane Pyrimidine Dimers and 6-4 Photoproducts. Nuc. Acids Res. 22, 3026-3032 .

  • Kim, S.T., Malhotra, K., Smith C.A., Taylor, J.-S. & Sancar, A. (1994). Characterization of (6-4) Photoproduct DNA Photolyase. J. Biol. Chem. 269, 8535-8540. pdf file (2,393 KB)

  • Reardon, J.T., Nichols, A.F., Keeney, S., Smith, C.A., Taylor, J.-S., Linn, S. & Sancar, A. (1993). Comparative Analysis of Binding of Human Damaged DNA-Binding Protein (XPE) and Escherichia coli Damage Recognition Protein (UvrA) to the Major Ultraviolet Photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T. J. Biol. Chem. 268, 21301-21308. pdf file (4,738 KB)

  • Kim, S.T., Malhorta, K., Smith, C.A., Taylor, J.-S. & Sancar, A. (1993). DNA Photolyase Repairs the Trans-Syn Cyclobutane Thymine Dimer. Biochemistry 32, 7065-7068. pdf file (900KB)

  • Smith, C.A. & Taylor, J.-S. (1993). Preparation and Characterization of a Set of Deoxyoligonucleotide 49-mers Containing Site-Specific Cis-Syn, Trans-Syn-I, (6-4), and Dewar Photoproducts of Thymidylyl(3'-5')-Thymidine. J. Biol. Chem. 268, 11143-11151. pdf file (4,460 KB)

  • Svoboda, D.L., Smith, C.A., Taylor, J.-S. & Sancar, A. (1993). Effect of Sequence, Adduct Type, and Opposing Lesions on the Binding and Repair of Ultraviolet Photodamage by DNA Photolyase and (A)BC Excinuclease. J. Biol. Chem. 268, 10694-10700. pdf file (4,169 KB)

  • Bennet, R.M., Hefeneider, S.H., Bakke, Antony, Merritt, M., Smith, C.A., Mourich, D., and Heinrich, M.C. (1988). The production and characterization of murine monoclonal antibodies to a DNA receptor on human leukocytes. J. Immunol. 140: 2937-2942. pdf file (3,152 KB)